Binding bacteria to highly branched poly(N-isopropyl acrylamide) modified with vancomycin induces the coil-to-globule transition

J Am Chem Soc. 2010 Feb 17;132(6):1736-7. doi: 10.1021/ja907466y.

Abstract

Binding of highly branched poly(N-isopropylacrylamide) with vancomycin end groups to Staphylococcus aureus induced a coil-to-globule phase transition. The polymers aggregated this gram-positive bacteria (but not gram-negative bacteria) over a wide range of temperatures, but cooling to 24-26 degrees C progressed the polymer-bound bacteria through a globule-to-coil phase transition, after which the bacteria were released.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry*
  • Acrylamides / metabolism*
  • Acrylic Resins
  • Bacteria / metabolism*
  • Polymers / chemistry*
  • Polymers / metabolism*
  • Spectrometry, Fluorescence
  • Temperature
  • Vancomycin / chemistry*

Substances

  • Acrylamides
  • Acrylic Resins
  • Polymers
  • poly-N-isopropylacrylamide
  • Vancomycin