Comparison of the duration of antimicrobial activity of 2 different antimicrobial central venous catheters

Infect Control Hosp Epidemiol. 2010 Mar;31(3):295-7. doi: 10.1086/650757.

Abstract

We compared the duration of antimicrobial effectiveness of 2 different antimicrobial catheters. The baseline activity of minocycline-rifampin catheters was greater than that of silver-platinum-carbon catheters against Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus faecalis. The antimicrobial activity of the minocycline-rifampin catheters against these pathogens persisted for up to 12 days, while that of the silver-platinum-carbon catheters was depleted by day 10 (P < .05).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / pharmacology
  • Bacterial Adhesion / drug effects
  • Catheterization, Central Venous / adverse effects
  • Catheterization, Central Venous / instrumentation*
  • Catheters, Indwelling / microbiology*
  • Gram-Positive Bacteria / drug effects*
  • Gram-Positive Bacteria / growth & development
  • Massachusetts
  • Minocycline / pharmacology
  • Rifampin / pharmacology

Substances

  • Anti-Infective Agents
  • Minocycline
  • Rifampin