PPARs: Diverse Regulators in Energy Metabolism and Metabolic Diseases

Cell Res. 2010 Feb;20(2):124-37. doi: 10.1038/cr.2010.13. Epub 2010 Jan 26.

Abstract

The nuclear receptor PPARs are fundamentally important for energy homeostasis. Through their distinct yet overlapping functions and tissue distribution, the PPARs regulate many aspects of energy metabolism at the transcriptional level. Functional impairment or dysregulation of these receptors leads to a variety of metabolic diseases, while their ligands offer many metabolic benefits. Studies of these receptors have advanced our knowledge of the transcriptional basis of energy metabolism and helped us understand the pathogenic mechanisms of metabolic syndrome.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adipogenesis / drug effects
  • Adipogenesis / genetics
  • Adipogenesis / physiology
  • Animals
  • Energy Metabolism / genetics*
  • Humans
  • Insulin Resistance / genetics
  • Insulin Resistance / physiology
  • Metabolic Diseases / genetics*
  • Models, Biological
  • Peroxisome Proliferator-Activated Receptors / agonists
  • Peroxisome Proliferator-Activated Receptors / genetics
  • Peroxisome Proliferator-Activated Receptors / metabolism
  • Peroxisome Proliferator-Activated Receptors / physiology*
  • Thiazolidinediones / pharmacology

Substances

  • Peroxisome Proliferator-Activated Receptors
  • Thiazolidinediones