Hyperpolarized 89Y complexes as pH sensitive NMR probes

J Am Chem Soc. 2010 Feb 17;132(6):1784-5. doi: 10.1021/ja910278e.


Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Hydrogen-Ion Concentration
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Molecular Probes / chemistry*
  • Organometallic Compounds / chemistry*
  • Yttrium / chemistry*


  • Ligands
  • Molecular Probes
  • Organometallic Compounds
  • Yttrium