The impact of cytomegalovirus infection ≥1 year after primary renal transplantation

Clin Transplant. 2010 Jul-Aug;24(4):572-7. doi: 10.1111/j.1399-0012.2010.01208.x.

Abstract

We studied the impact of a first post-transplant cytomegalovirus (CMV) infection greater than one year after primary kidney transplantation. Risk factors for developing late CMV were acute rejection and donor-recipient CMV status. Of those developing late CMV, 35% were donor (D) positive, recipient (R) negative; however, 23% were D+R+, 22% D-R+, and 15% D-R-. Late CMV was associated with significantly decreased patient and graft survival.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antiviral Agents / therapeutic use
  • Child
  • Child, Preschool
  • Cytomegalovirus / pathogenicity*
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / etiology*
  • Cytomegalovirus Infections / mortality
  • Female
  • Follow-Up Studies
  • Graft Rejection / virology*
  • Graft Survival / physiology*
  • Humans
  • Kidney Transplantation / adverse effects*
  • Kidney Transplantation / mortality*
  • Male
  • Middle Aged
  • Risk Factors
  • Survival Rate
  • Time Factors
  • Treatment Outcome
  • Young Adult

Substances

  • Antiviral Agents