Colorectal cancer is one of the most common neoplasms in western countries and is a worldwide public health problem. A substantial number of cases show familial aggregation of the disease, termed familial colorectal cancer to distinguish it from well-established hereditary forms. The present review discusses current knowledge of the underlying genetic causes, the most appropriate screening strategies and the potential prognostic implications of this entity.
2009 Elsevier España, S.L. All rights reserved.