Synthesis and in vitro antiproliferative activities of quinoline derivatives

Sidonie Broch; Bettina Aboab; Fabrice Anizon; Pascale Moreau

doi:10.1016/j.ejmech.2010.01.003

Synthesis and in vitro antiproliferative activities of quinoline derivatives

Eur J Med Chem. 2010 Apr;45(4):1657-62. doi: 10.1016/j.ejmech.2010.01.003. Epub 2010 Jan 14.

Authors

Sidonie Broch¹, Bettina Aboab, Fabrice Anizon, Pascale Moreau

Affiliation

¹ Clermont Université, Université Blaise Pascal, Laboratoire SEESIB, BP 10448, F-63000 Clermont-Ferrand, France.

PMID: 20106562
DOI: 10.1016/j.ejmech.2010.01.003

Abstract

The synthesis of new di- and trimeric quinoline derivatives is described as well as their in vitro antiproliferative activities toward a human fibroblast primary culture and two human solid cancer cell lines (MCF-7 and PA 1).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Cell Proliferation / drug effects*
Humans
In Vitro Techniques
Magnetic Resonance Spectroscopy
Mass Spectrometry
Quinolines / chemical synthesis*
Quinolines / pharmacology*
Spectrophotometry, Infrared

Substances

Quinolines