Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Feb;61(2):107-8, 110-4.
doi: 10.1007/s00105-009-1830-1.

[Acne Vulgaris. The Role of Hormones]

[Article in German]
Affiliations

[Acne Vulgaris. The Role of Hormones]

[Article in German]
C C Zouboulis. Hautarzt. .

Abstract

Peripherally active androgens control cellular functions by binding to androgen receptors. Follicular keratinocytes and sebocytes are target cells for androgens, which, directly or indirectly, stimulate keratinocyte proliferation and the volume of sebaceous glands as well as the sebum secretion rate. Acne often begins with the adrenarche, namely with the up- regulation of adrenal synthesis of dehydroepiandrosterone sulfate, a hormone that is upstream to testosterone. The majority of acne patients exhibit normal levels of circulating androgens, while sebaceous glands from acne regions exhibit a stronger sensitivity to androgens than the sebaceous glands from other parts of the body. Hormone-like active lipids, hormones in diet and neuropeptides may also play a role in the development of acne lesions. The target of antiandrogen treatment of the skin is mainly the sebaceous gland and the primary effect is sebostasis.

Similar articles

  • [How acne vulgaris develops].
    Plewig G. Plewig G. Hautarzt. 2010 Feb;61(2):99-100, 102-4, 106. doi: 10.1007/s00105-009-1829-7. Hautarzt. 2010. PMID: 20084358 German.
  • Acne and sebaceous gland function.
    Zouboulis CC. Zouboulis CC. Clin Dermatol. 2004 Sep-Oct;22(5):360-6. doi: 10.1016/j.clindermatol.2004.03.004. Clin Dermatol. 2004. PMID: 15556719 Review.
  • [The sebaceous gland].
    Zouboulis CC. Zouboulis CC. Hautarzt. 2010 Jun;61(6):467-8, 4704, 476-7. doi: 10.1007/s00105-009-1894-y. Hautarzt. 2010. PMID: 20512305 Review. German.
  • Acne: hormonal concepts and therapy.
    Thiboutot D. Thiboutot D. Clin Dermatol. 2004 Sep-Oct;22(5):419-28. doi: 10.1016/j.clindermatol.2004.03.010. Clin Dermatol. 2004. PMID: 15556729 Review.
  • Endocrine aspects of acne.
    Lucky AW. Lucky AW. Pediatr Clin North Am. 1983 Jun;30(3):495-9. doi: 10.1016/s0031-3955(16)34397-8. Pediatr Clin North Am. 1983. PMID: 6224126 Review.
See all similar articles

Cited by 5 articles

References

    1. Br J Dermatol. 2009 Feb;160(2):345-52 - PubMed
    1. Dermatology. 1998;196(4):453-4 - PubMed
    1. World Rev Nutr Diet. 2001;88:18-27 - PubMed
    1. Br J Dermatol. 2000 Jun;142(6):1084-91 - PubMed
    1. Dermatology. 1998;196(1):38-42 - PubMed

Publication types

LinkOut - more resources

Feedback