Association between the -402GA, -401GT, and -323ins10-bp polymorphisms of factor VII gene and breast cancer

Breast Cancer. 2011 Oct;18(4):282-5. doi: 10.1007/s12282-009-0189-6. Epub 2010 Jan 27.


Background and purpose: Recent data have shown that the hemostatic system may play a role in cancer development and progression. To test whether factor VII (FVII) can be a candidate factor for breast cancer, we have evaluated the distribution of FVII gene polymorphisms in breast cancer patients and healthy subjects.

Methods: The nested case-control study consisted of 92 women with breast cancer (group 1) and 80 control subjects (in age-matched women) (group 2). Genotyping of the -323ins10-bp, -401GT, and -402GA polymorphisms of the FVII gene was performed by the method of single-strand conformation polymorphism analysis and sequencing.

Results: A significant difference was observed in the distribution of the -402GA genotype and allele frequencies in breast cancer and control cases (p < 0.05). For other polymorphisms of the FVII gene, the distributions of genotypes and allele frequencies were not significantly different between two groups (p > 0.05). There was also a significant difference between the distributions of the haplotypes in breast cancer patients and control subjects (p < 0.05).

Conclusion: Although the number of cases in this study was small, the preliminary findings revealed a possible contribution of the FVII -402GA polymorphism in the development of breast cancer. However, further case-control studies with larger series are needed to confirm our findings.

MeSH terms

  • Breast Neoplasms / genetics*
  • Case-Control Studies
  • Factor VII / genetics*
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Polymorphism, Single-Stranded Conformational*


  • Factor VII