Hyperthyroidism--cause of depression and psychosis: a case report

J Med Life. 2009 Oct-Dec;2(4):440-2.


Psychiatric symptoms have been reported quite frequently in certain thyroid diseases, but more frequently in association with hypothyroidism. Thyrotoxicosis can be associated with various psychiatric symptoms, such as emotional lability, anxiety, restlessness and rarely frank psychosis. Psychotic symptoms in the context of hyperthyroidism typically present as an affective psychosis. The link between psychosis and hyperthyroidism is poorly understood. Because of this association of psychiatric symptoms is important to exclude a somatic cause, when assessing a patient first. We present the case of young woman who was followed over 2 years and who initially presented to psychiatric consultation for depressive symptoms, after being diagnosed with hyperthyroidism and specific therapy instituted, but who developed psychotic symptoms.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antithyroid Agents / therapeutic use
  • Depression / etiology*
  • Female
  • Humans
  • Hyperthyroidism / diagnosis
  • Hyperthyroidism / psychology*
  • Hyperthyroidism / surgery
  • Propylthiouracil / therapeutic use*
  • Psychotic Disorders / etiology*
  • Thyroidectomy*


  • Antithyroid Agents
  • Propylthiouracil