Insulin-sensitivity response to a single bout of resistive exercise in type 1 diabetes mellitus

J Sport Rehabil. 2009 Nov;18(4):564-71. doi: 10.1123/jsr.18.4.564.


Context: Little is known about the acute effects of resistance exercise on insulin sensitivity in people with type 1 diabetes.

Design: Repeated-measures design with 2 independent variables: group (exercise and nonexercise control) and time (preexercise and 12 and 36 h postexercise).

Setting: General Clinical Research Center, Temple University Hospital, Philadelphia, PA.

Patients: 14 physically active subjects (11 men and 3 women) with type 1 diabetes.

Intervention: The exercise group completed 5 sets of 6 repetitions of strenuous (80% 1-RM) quadriceps and hamstring exercises while the control group performed only activities of daily living.

Main outcome measures: Insulin sensitivity was assessed with the euglycemic-hyperinsulinemic-clamp technique preexercise and 12 and 36 h postexercise.

Results: Insulin-sensitivity values were not significantly different between the exercise and control groups (P = .92) or over time (P = .67).

Conclusions: A single bout of strenuous resistance exercise does not alter insulin sensitivity in people with type 1 diabetes.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Adult
  • Analysis of Variance
  • Blood Glucose*
  • Diabetes Mellitus, Type 1 / metabolism*
  • Exercise Test
  • Female
  • Glucose Clamp Technique
  • Humans
  • Insulin / metabolism
  • Insulin Resistance*
  • Isometric Contraction / physiology
  • Male
  • Motor Activity
  • Muscle, Skeletal / physiology
  • Resistance Training*
  • Surveys and Questionnaires
  • Weight Lifting*
  • Young Adult


  • Blood Glucose
  • Insulin