A case-control study of the risk factors associated with sinonasal inverted papilloma

Am J Rhinol Allergy. Jan-Feb 2010;24(1):e37-40. doi: 10.2500/ajra.2010.24.3408.


Background: The etiology of sinonasal inverted papilloma (IP) is unknown. This study was designed to evaluate the possible risk factors associated with IP Methods: This is a case-control epidemiology study in a tertiary referral center. Fifty patients with IP and 150 matched controls were interviewed using a questionnaire on suspected risk factors. Univariate analysis of the risk factors and calculation of the matched odds ratios, the corresponding 95% CIs, and p values was performed. Significant risk factors were further studied using conditional logistic regression analysis.

Results: Outdoor and industrial occupations were associated with IP. Tobacco smoking, drinking alcohol, history of allergic rhinitis, sinusitis, nasal polyp, non-sinonasal papilloma and non-sinonasal malignancy were not significant factors.

Conclusion: Outdoor and industrial occupations were associated with IP and may be potential risk factors. Future studies are warranted to further evaluate the individual type of occupation and chemical involved.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Environmental Exposure
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nose Neoplasms / epidemiology*
  • Nose Neoplasms / pathology
  • Nose Neoplasms / physiopathology
  • Occupational Exposure
  • Papilloma, Inverted / epidemiology*
  • Papilloma, Inverted / pathology
  • Papilloma, Inverted / physiopathology
  • Paranasal Sinuses / pathology*
  • Risk Factors
  • Smoking