Insulin resistance in the spontaneously hypertensive rat

Metabolism. 1991 Apr;40(4):359-61. doi: 10.1016/0026-0495(91)90145-m.


To determine experimentally if insulin resistance is associated with spontaneously occurring hypertension, insulin-stimulated glucose metabolism was studied in an animal model of genetic hypertension. The spontaneously hypertensive rat (SHR) and its genetic control, the Wistar-Kyoto strain (WKY) were studied with the euglycemic hyperinsulinemic clamp technique. Clamp studies demonstrated reduced insulin-stimulated glucose uptake in SHR (P less than .001). These data indicate that SHR is insulin-resistant when compared with WKY. A reduction of insulin-stimulated glucose metabolism occurred in older animals of both strains, providing evidence of an aging effect on insulin-stimulated glucose metabolism. However, the reduction of insulin-stimulated glucose metabolism was more pronounced in the hypertensive animals. This study demonstrates the presence of peripheral (skeletal muscle) insulin resistance in the SHR.

MeSH terms

  • Animals
  • Blood Glucose / metabolism*
  • Glucose Clamp Technique
  • Hypertension / blood*
  • Insulin / pharmacology*
  • Insulin Resistance*
  • Kinetics
  • Male
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY


  • Blood Glucose
  • Insulin