A novel exon in AML1-ETO negatively influences the clonogenic potential of the t(8;21) in acute myeloid leukemia

Leukemia. 2010 Apr;24(4):891-4. doi: 10.1038/leu.2009.288. Epub 2010 Jan 28.

Authors

D Mannari, D Gascoyne, J Dunne, T Chaplin, B Young

PMID: 20111069
DOI: 10.1038/leu.2009.288

No abstract available

Publication types

Letter

MeSH terms

Adolescent
Adult
Aged
Alternative Splicing*
Blotting, Western
Chromosomes, Human, Pair 21 / genetics*
Chromosomes, Human, Pair 8 / genetics*
Clone Cells
Core Binding Factor Alpha 2 Subunit / genetics*
Exons / genetics*
Female
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology
Male
Middle Aged
Oncogene Proteins, Fusion / genetics*
RNA, Messenger / genetics
RNA, Messenger / metabolism
RUNX1 Translocation Partner 1 Protein
Reverse Transcriptase Polymerase Chain Reaction
Translocation, Genetic / genetics*
Tumor Stem Cell Assay
Young Adult

Substances

AML1-ETO fusion protein, human
Core Binding Factor Alpha 2 Subunit
Oncogene Proteins, Fusion
RNA, Messenger
RUNX1 Translocation Partner 1 Protein