Effect of the polysaccharide extract from the edible mushroom Pleurotus ostreatus against infectious bursal disease virus

Int J Mol Sci. 2009 Aug 18;10(8):3616-3634. doi: 10.3390/ijms10083616.


The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects. Being aware of these therapeutic effects of mushroom extracts, we have investigated the synergistic relations between these extracts and BIAVAC and BIAROMVAC vaccines. These vaccines target the stimulation of the immune system in commercial poultry, which are extremely vulnerable in the first days of their lives. By administrating EF with polysaccharides from P. ostreatus to unvaccinated broilers we have noticed slow stimulation of maternal antibodies against infectious bursal disease (IBD) starting from four weeks post hatching. For the broilers vaccinated with BIAVAC and BIAROMVAC vaccines a low to almost complete lack of IBD maternal antibodies has been recorded. By adding 5% and 15% EF in the water intake, as compared to the reaction of the immune system in the previous experiment, the level of IBD antibodies was increased. This has led us to believe that by using this combination of BIAVAC and BIAROMVAC vaccine and EF from P. ostreatus we can obtain good results in stimulating the production of IBD antibodies in the period of the chicken first days of life, which are critical to broilers' survival. This can be rationalized by the newly proposed reactivity biological activity (ReBiAc) principles by examining the parabolic relationship between EF administration and recorded biological activity.

Keywords: BIAVAC & BIAROMVAC vaccines; Gumboro disease; ReBiAc principles; extracellular fraction.

MeSH terms

  • Animals
  • Antibodies / immunology
  • Birnaviridae Infections / immunology
  • Birnaviridae Infections / prevention & control
  • Birnaviridae Infections / veterinary*
  • Chickens
  • Drug Synergism
  • Immunologic Factors / chemistry
  • Immunologic Factors / isolation & purification
  • Immunologic Factors / pharmacology
  • Infectious bursal disease virus / drug effects*
  • Infectious bursal disease virus / immunology
  • Pleurotus / chemistry*
  • Pleurotus / metabolism
  • Polysaccharides / chemistry
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Viral Vaccines / immunology


  • Antibodies
  • Immunologic Factors
  • Polysaccharides
  • Viral Vaccines