Interleukin 18 in the CNS

J Neuroinflammation. 2010 Jan 29;7:9. doi: 10.1186/1742-2094-7-9.

Abstract

Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases of the Nervous System / complications
  • Autoimmune Diseases of the Nervous System / metabolism
  • Autoimmune Diseases of the Nervous System / pathology
  • Central Nervous System / immunology
  • Central Nervous System / metabolism*
  • Humans
  • Inflammation / metabolism
  • Inflammation / pathology
  • Interleukin-18 / metabolism*
  • Mental Disorders / immunology
  • Mental Disorders / metabolism
  • Mental Disorders / pathology
  • Microglia / immunology
  • Microglia / metabolism
  • Neurodegenerative Diseases / complications
  • Neurodegenerative Diseases / immunology
  • Neurodegenerative Diseases / pathology
  • Receptors, Interleukin-8 / metabolism
  • Signal Transduction / physiology
  • Stress, Psychological / metabolism
  • Stress, Psychological / pathology

Substances

  • Interleukin-18
  • Receptors, Interleukin-8