Mineral trioxide aggregate: a comprehensive literature review--part II: leakage and biocompatibility investigations

J Endod. 2010 Feb;36(2):190-202. doi: 10.1016/j.joen.2009.09.010.


Introduction: Mineral trioxide aggregate (MTA) was developed because existing materials did not have the ideal characteristics for orthograde or retrograde root-end fillings. MTA has been recommended primarily as a root-end filling material, but it has also been used in pulp capping, pulpotomy, apical barrier formation in teeth with open apexes, repair of root perforations, and root canal filling. Part I of this literature review presented a comprehensive list of articles regarding the chemical and physical properties as well as the antibacterial activity of MTA. The purpose of part II of this review is to present a comprehensive list of articles regarding the sealing ability and biocompatibility of this material.

Methods: A review of the literature was performed by using electronic and hand-searching methods for the sealing ability and biocompatibility of MTA from November 1993-September 2009.

Results: Numerous studies have investigated the sealing ability and biocompatibility of MTA.

Conclusions: On the basis of available evidence it appears that MTA seals well and is a biocompatible material.

Publication types

  • Review

MeSH terms

  • Aluminum Compounds* / chemistry
  • Aluminum Compounds* / pharmacology
  • Aluminum Compounds* / therapeutic use
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology
  • Biocompatible Materials / therapeutic use
  • Calcium Compounds* / chemistry
  • Calcium Compounds* / pharmacology
  • Calcium Compounds* / therapeutic use
  • Dental Cements
  • Dental Leakage*
  • Drug Combinations
  • Humans
  • Oxides* / chemistry
  • Oxides* / pharmacology
  • Oxides* / therapeutic use
  • Root Canal Filling Materials*
  • Silicates* / chemistry
  • Silicates* / pharmacology
  • Silicates* / therapeutic use


  • Aluminum Compounds
  • Biocompatible Materials
  • Calcium Compounds
  • Dental Cements
  • Drug Combinations
  • Oxides
  • Root Canal Filling Materials
  • Silicates
  • mineral trioxide aggregate