Rearrangement and overexpression of D11S287E, a candidate oncogene on chromosome 11q13 in benign parathyroid tumors

Oncogene. 1991 Mar;6(3):449-53.


We report the detailed molecular characterization of a human parathyroid adenoma with a clonal parathyroid hormone gene rearrangement. This rearrangement is similar to one we characterized recently in an independent adenoma. In these two, plus a third partially characterized adenoma, one allele of the PTH gene, on 11p15, is rearranged with DNA from the D11S287 region on 11q13. This region contains a transcribed sequence, D11S287E, distinct from known 11q13 oncogenes, that is expressed in all parathyroid tissues examined, but is overexpressed dramatically in all three tumours with PTH gene-D11S287 rearrangements. These findings suggest that overexpression of D11S287E, perhaps driven by the misplaced PTH gene's regulatory elements, contributed to the development of these benign tumors. D11S287E is a new candidate oncogene with potential importance in parathyroid adenomas and perhaps other tumors with 11q13 abnormalities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoma / genetics*
  • Blotting, Northern
  • Blotting, Southern
  • Chromosomes, Human, Pair 11*
  • DNA, Neoplasm / analysis
  • DNA, Neoplasm / genetics
  • Gene Expression Regulation, Neoplastic*
  • Gene Rearrangement*
  • Humans
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Parathyroid Hormone / genetics
  • Parathyroid Neoplasms / genetics*
  • RNA, Neoplasm / analysis
  • RNA, Neoplasm / genetics
  • Restriction Mapping


  • DNA, Neoplasm
  • Parathyroid Hormone
  • RNA, Neoplasm