Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Apr;60(2):127-39.
doi: 10.1016/j.patbio.2009.11.003. Epub 2010 Feb 8.

[Cytokines in Systemic Sclerosis]

[Article in French]
Affiliations
Review

[Cytokines in Systemic Sclerosis]

[Article in French]
J Baraut et al. Pathol Biol (Paris). .

Abstract

The balance in the production and release of cytokines "Th1/Th2" or "Th17" or "regulatory T" is one of the key events in the pathogenesis of systemic sclerosis (SSc). Specifically, the Th2 cytokine response, characterized by the production of IL-4, IL-10 and TGF-β, leads to tissue fibrosis in patients with SSc. Many studies have shown the importance of analyzing the levels of cytokines as diagnostic or prognostic markers in the blood or in situ in patients with SSc. The restoration of the Th1/Th2/Th17/Treg balance will contribute to the effectiveness of treatment and the use of cytokine modulators may therefore be considered in developing new therapeutic approaches.

Similar articles

See all similar articles

Cited by 3 articles

LinkOut - more resources

Feedback