The FANCM family of DNA helicases/translocases

DNA Repair (Amst). 2010 Mar 2;9(3):224-36. doi: 10.1016/j.dnarep.2009.12.012. Epub 2010 Feb 8.


FANCM and its relatives, Hef, Mph1 and Fml1, are DNA junction-specific helicases/translocases that target and process perturbed replication forks and intermediates of homologous recombination. They have variously been implicated in promoting the activation of the S-phase checkpoint, recruitment of the Fanconi Anemia Core Complex to sites of DNA damage, crossover avoidance during DNA double-strand break repair by homologous recombination, and the replicative bypass of DNA lesions by template switching. This review summarises our current understanding of the biochemical activities and biological functions of the FANCM family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA / metabolism
  • DNA Helicases / metabolism*
  • DNA Repair
  • DNA Replication
  • Humans
  • Protein Binding


  • DNA
  • DNA Helicases