The effects of FG 7142 on sensory-specific satiety in rats

Behav Brain Res. 2010 May 1;209(1):131-6. doi: 10.1016/j.bbr.2010.01.034. Epub 2010 Jan 29.


Three experiments used intake, clusters, and licks per cluster to study the effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in rats. In Experiment 1, rats were offered one of two palatable solutions and 30min later tested with the same or the other solution. Rats that received the same solution consumed less, exhibited fewer clusters, fewer licks per cluster and a more rapid decline in rate of licking than rats tested with the other solution. In Experiments 2 and 3, rats tested with the same solution under FG 7142 showed fewer clusters and fewer licks per cluster than vehicle rats. Rats tested with the other solution under FG 7142 showed fewer licks per cluster but more clusters than vehicle rats. The results were discussed in terms of the distinction between "liking" and "wanting" and the role of GABA in the former but not the latter.

MeSH terms

  • Animals
  • Appetite Depressants / pharmacology*
  • Carbolines / pharmacology*
  • Dietary Sucrose / administration & dosage
  • Feeding Behavior / drug effects*
  • Food Preferences / drug effects
  • Food, Formulated
  • Male
  • Rats
  • Rats, Wistar
  • Recognition, Psychology / drug effects
  • Satiation / drug effects*
  • Sensation / drug effects*
  • Sensation / physiology
  • Sucrose / administration & dosage
  • Sweetening Agents / administration & dosage


  • Appetite Depressants
  • Carbolines
  • Dietary Sucrose
  • Sweetening Agents
  • Ensure formulated food
  • Sucrose
  • FG 7142