Health-related quality of life across pediatric chronic conditions

J Pediatr. 2010 Apr;156(4):639-44. doi: 10.1016/j.jpeds.2009.11.008. Epub 2010 Feb 1.


Objective: To compare health-related quality of life (HRQOL) across 8 pediatric chronic conditions, including 5 understudied populations, and examine convergence between youth self-report and parent-proxy report.

Study design: Secondary data from 589 patients and their caregivers were collected across the following conditions: obesity, eosinophilic gastrointestinal disorder, inflammatory bowel disease, epilepsy, type 1 diabetes, sickle cell disease, post-renal transplantation, and cystic fibrosis. Youth and caregivers completed age-appropriate self-report and/or parent-proxy report generic HRQOL measures.

Results: Youth diagnosed with eosinophilic gastrointestinal disorder and obesity had lower HRQOL than other pediatric conditions by parent report. Caregivers reported lower HRQOL by proxy report than youth self-reported across most subscales.

Conclusions: Use of brief, easily administered, and reliable assessments of psychosocial functioning, such as HRQOL, may provide clinicians additional opportunities for intervention or services targeting improved HRQOL relative to the needs of each population.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Chronic Disease / ethnology
  • Chronic Disease / psychology*
  • Ethnicity
  • Female
  • Follow-Up Studies
  • Health Status*
  • Humans
  • Male
  • Morbidity
  • Parent-Child Relations / ethnology
  • Quality of Life*
  • Retrospective Studies
  • United States / epidemiology