Distinct ethnic differences in lipid profiles across glucose categories

J Clin Endocrinol Metab. 2010 Apr;95(4):1793-801. doi: 10.1210/jc.2009-2348. Epub 2010 Jan 29.

Abstract

Context: Dyslipidemia coexists with hyperglycemia. However, little is known about the ethnic differences in lipid profiles at comparable glucose tolerance status.

Objective: The aim was to study ethnic differences in lipid profiles stratified by glucose levels.

Design and setting: Data from 31 study cohorts of 12 countries, consisting of 24,760 men and 27,595 women aged 25-74 yr, were compared. The odds ratio for having dyslipidemia was estimated for each ethnic group stratified by glucose categories.

Results: Compared with central and northern Europeans, multivariable adjusted odds ratios (95% confidence intervals) for having lower high-density lipoprotein-cholesterol were 4.74 (4.19-5.37), 5.05 (3.88-6.56), 3.07 (2.15-4.40), and 2.37 (1.67-3.35) in Asian Indian men, but 0.12 (0.09-0.16), 0.07 (0.04-0.13), 0.11 (0.07-0.20), and 0.16 (0.08-0.32) in Chinese men who had normoglycemia, prediabetes, and undiagnosed and diagnosed diabetes, respectively. Similar results were obtained for women. The prevalence of low high-density lipoprotein-cholesterol remained higher in Asian Indians (62.8% of the nondiabetic and 67.4% of the diabetic) than in central and northern Europeans (20.3 and 37.3%), Japanese (25.7 and 34.1%), or Qingdao Chinese (15.7 and 17.0%), even in individuals with low-density lipoprotein-cholesterol of less than 3 mmol/liter.

Conclusion: There are distinct patterns of lipid profiles associated with ethnicity regardless of the glucose levels, suggesting that ethnic-specific strategies and guidelines on risk assessment and prevention of cardiovascular disease are required.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Asia / epidemiology
  • Asian Continental Ancestry Group
  • Blood Glucose / metabolism*
  • Body Mass Index
  • Cholesterol / blood
  • Cohort Studies
  • Diabetes Mellitus / blood
  • Ethnic Groups / statistics & numerical data*
  • Europe / epidemiology
  • European Continental Ancestry Group
  • Female
  • Glucose Tolerance Test
  • Humans
  • Lipids / blood*
  • Lipoproteins / blood
  • Male
  • Middle Aged
  • Odds Ratio
  • Reference Standards
  • Sex Characteristics

Substances

  • Blood Glucose
  • Lipids
  • Lipoproteins
  • Cholesterol