Air pollution positively correlates with daily stroke admission and in hospital mortality: a study in the urban area of Como, Italy

Neurol Sci. 2010 Apr;31(2):179-82. doi: 10.1007/s10072-009-0206-8. Epub 2010 Jan 30.


Some current evidences suggest that stroke incidence and mortality may be higher in elevated air pollution areas. Our study examined the hypothesis of a correlation between air pollution level and ischemic stroke admission and in Hospital mortality in an urban population. Data on a total of 759 stroke admissions and 180 deaths have been obtained over a 4-year period (2000-2003). Five air ambient particles have been studied. A general additive model estimating Poisson distribution has been used, adding meteorological variables as covariates. NO(2) and PM(10) were significantly associated with admission and mortality (P value < 0.05) and with estimated RR of 1.039 (95% CI 1.066-1.013) and 1.078 (95% CI 1.104-1.052) for hospital admission at 2- and 4-day lags, respectively. In conclusion, this study suggests an association between short-term outdoor air pollution exposure and ischemic stroke admission and mortality.

MeSH terms

  • Aged
  • Air Pollution*
  • Brain Ischemia / epidemiology*
  • Brain Ischemia / mortality
  • Brain Ischemia / therapy
  • Female
  • Hospital Mortality*
  • Hospitalization*
  • Humans
  • Italy / epidemiology
  • Male
  • Models, Statistical
  • Nitrogen Dioxide / analysis
  • Particulate Matter / analysis
  • Poisson Distribution
  • Stroke / epidemiology*
  • Stroke / mortality
  • Stroke / therapy
  • Time Factors
  • Urban Population


  • Particulate Matter
  • Nitrogen Dioxide