Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee)

Am J Clin Nutr. 1991 Apr;53(4 Suppl):1021S-1026S. doi: 10.1093/ajcn/53.4.1021S.

Abstract

A double-blind, crossover, 8-wk study was conducted to compare effects of the tocotrienol-enriched fraction of palm oil (200 mg palmvitee capsules/day) with those of 300 mg corn oil/d on serum lipids of hypercholesterolemic human subjects (serum cholesterol 6.21-8.02 mmol/L). Concentrations of serum total cholesterol (-15%), LDL cholesterol (-8%), Apo B (-10%), thromboxane (-25%), platelet factor 4 (-16%), and glucose (-12%) decreased significantly only in the 15 subjects given palmvitee during the initial 4 wk. The crossover confirmed these actions of palmvitee. There was a carry over effect of palmvitee. Serum cholesterol concentrations of seven hypercholesterolemic subjects (greater than 7.84 mmol/L) decreased 31% during a 4-wk period in which they were given 200 mg gamma-tocotrienol/d. This indicates that gamma-tocotrienol may be the most potent cholesterol inhibitor in palmvitee capsules. The results of this pilot study are very encouraging.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / therapeutic use*
  • Apolipoproteins / analysis
  • Cholesterol / blood*
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Chromans*
  • Double-Blind Method
  • Female
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / drug therapy*
  • Lipoproteins, HDL / blood
  • Male
  • Middle Aged
  • Platelet Aggregation
  • Platelet Factor 4 / analysis
  • Thromboxane B2 / blood
  • Triglycerides / blood
  • Vitamin E / administration & dosage
  • Vitamin E / analogs & derivatives*
  • Vitamin E / blood
  • Vitamin E / therapeutic use

Substances

  • Antioxidants
  • Apolipoproteins
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Chromans
  • Lipoproteins, HDL
  • Triglycerides
  • Vitamin E
  • Platelet Factor 4
  • plastochromanol 8
  • Thromboxane B2
  • Cholesterol