Dapsone gel 5% in combination with adapalene gel 0.1%, benzoyl peroxide gel 4% or moisturizer for the treatment of acne vulgaris: a 12-week, randomized, double-blind study

J Drugs Dermatol. 2010 Jan;9(1):33-40.


Purpose: To evaluate the safety and efficacy of dapsone gel 5% in the treatment of acne when used in combination with adapalene gel 0.1%, benzoyl peroxide gel 4% or moisturizer.

Methods: This was a twelve-week, randomized, double-blind study. Patients aged 12 years and older (n=301) applied dapsone gel twice daily and were randomly assigned (1:1:1) to one of three additional treatments, applied once daily.

Results: By week 12, dapsone gel combined with any of the three additional treatments reduced the mean number of inflammatory lesions. However, the authors did not detect a significant difference in the reduction of inflammatory lesions when dapsone was used in combination with adapalene gel or with benzoyl peroxide gel compared to the dapsone plus moisturizer combination group (P=0.052 for both versus moisturizer combination). Patients treated with dapsone gel combined with adapalene showed a significantly better response in reduction in non-inflammatory and total acne lesion count than those who received the moisturizer combination. Local adverse reactions in all three treatment groups were minimal and generally mild in severity.

Conclusion: Dapsone gel in combination with adapalene gel or benzoyl peroxide gel is safe and well tolerated for the treatment of acne vulgaris.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / pathology
  • Adapalene
  • Adolescent
  • Adult
  • Benzoyl Peroxide / administration & dosage
  • Benzoyl Peroxide / adverse effects
  • Benzoyl Peroxide / therapeutic use*
  • Child
  • Dapsone / administration & dosage
  • Dapsone / adverse effects
  • Dapsone / therapeutic use*
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / adverse effects
  • Dermatologic Agents / therapeutic use*
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Gels
  • Humans
  • Keratolytic Agents / administration & dosage
  • Keratolytic Agents / adverse effects
  • Keratolytic Agents / therapeutic use*
  • Male
  • Naphthalenes / administration & dosage
  • Naphthalenes / adverse effects
  • Naphthalenes / therapeutic use*
  • Treatment Outcome
  • Young Adult


  • Dermatologic Agents
  • Drug Combinations
  • Gels
  • Keratolytic Agents
  • Naphthalenes
  • Adapalene
  • Dapsone
  • Benzoyl Peroxide