Effects of Mangifera indica fruit extract on cognitive deficits in mice

J Environ Biol. 2009 Jul;30(4):563-6.


Mangos are a source of bioactive compounds with potential health-promoting activity. The present work was undertaken to evaluate the ethanolic extract of Mangifera indica L. fruit on cognitive performances. The models used to study the effect on cognitive performances are step down passive avoidance task and elevated plus maze task in mice. Chronic treatment (7 days) of extract and vitamin C significantly (p < 0.05) reversed the aging and scopolamine induced memory deficits in both paradigms. Preliminary phytochemical screening revealed the presence of free sugars, saponins, tannins, and flavonoids. The results suggestthe extract contained pharmacologically active principles that are memory-enhancing in nature.

MeSH terms

  • Animals
  • Ascorbic Acid / therapeutic use
  • Cognition Disorders / chemically induced
  • Cognition Disorders / drug therapy*
  • Female
  • Fruit / chemistry*
  • Male
  • Mangifera / chemistry*
  • Mice
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Scopolamine


  • Mangifera indica extract
  • Plant Extracts
  • Scopolamine
  • Ascorbic Acid