Serum tetranectin is a significant prognostic marker in ovarian cancer patients

Acta Obstet Gynecol Scand. 2010;89(2):190-8. doi: 10.3109/00016340903530936.


Objective: To evaluate the prognostic value of preoperative serum tetranectin (TN) in Danish ovarian cancer (OvCa) patients. Design. Population-based, multidisciplinary Danish case-control study of OvCa.

Participants: A total of 445 primary OvCa patients diagnosed at one of the gynecological departments in 18 regional hospitals around Denmark during the period 1994-1999.

Methods: Serum levels of TN were evaluated preoperatively and tested for possible association with prognosis.

Main outcome measures: Disease specific survival.

Results: During the observation period (median 45.9 months, range 0.2-121) 278 OvCa-related deaths were seen. Univariate analysis of TN and CA125 demonstrated a significant association with survival using the Cox proportional hazards model, when stratified for adjuvant treatment (TN: p < 0.0001, hazard ratio = 0.44; 95% confidence interval 0.33-0.60 and CA125: p < 0.0001, hazard ratio = 1.19; 95% confidence interval 1.11-1.27). Disease specific survival curves for patients with tumors in the early stages showed no significant association with survival, neither for TN (p = 0.68) nor for CA125 (p = 0.07). For the stage III group, a significant association with survival was found for TN (p = 0.027), but not for CA125 (p = 0.37). Multivariate Cox analysis identified TN, age, residual tumor, International Federation of Gynecology and Obstetrics stage and grade but not serum CA125 as independent prognostic variables.

Conclusion: Preoperative serum TN is a useful prognostic indicator of advanced stage for patients with OvCa.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / blood
  • CA-125 Antigen / blood
  • Carcinoma / blood
  • Carcinoma / mortality
  • Carcinoma / pathology
  • Carcinoma / surgery
  • Case-Control Studies
  • Denmark / epidemiology
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Lectins, C-Type / blood*
  • Middle Aged
  • Neoplasm, Residual / pathology
  • Ovarian Neoplasms / blood*
  • Ovarian Neoplasms / mortality*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Preoperative Care
  • Prognosis
  • Proportional Hazards Models
  • Registries


  • Biomarkers, Tumor
  • CA-125 Antigen
  • Lectins, C-Type
  • tetranectin