Effect of L-arginine on the microcirculation in the neuropathic diabetic foot in Type 2 diabetes mellitus: a double-blind, placebo-controlled study

Diabet Med. 2010 Jan;27(1):113-6. doi: 10.1111/j.1464-5491.2009.02876.x.


Objective: To investigate the effect of L-arginine on endothelial function, transcutaneous oxygen and clinical neuropathy in patients with peripheral neuropathy as a result of diabetes.

Research design and methods: Thirty diabetic patients with peripheral neuropathy were randomized to receive L-arginine (3 g three times daily) or placebo (3 g three times daily) for 3 months. All patients had foot microcirculation and foot transcutaneous oxygen pressure (TcPO(2)), neuropathy disability score (NDS) and vibration perception threshold (VPT) assessed at baseline and follow-up.

Results: No difference was observed in endothelium-dependent and -independent vasodilation, TcPO(2), NDS and VPT.

Conclusions: L-arginine has no effect on endothelial dysfunction, TcPO(2) and clinical neuropathy.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Arginine / therapeutic use*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Diabetic Foot / drug therapy
  • Diabetic Foot / physiopathology*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Microcirculation / drug effects
  • Microcirculation / physiology
  • Middle Aged
  • Placebos
  • Treatment Outcome


  • Placebos
  • Arginine