Synthesis, characterization and cytotoxic/cytostatic activity of La(III) and Dy(III) complexes

J Trace Elem Med Biol. 2010 Jan;24(1):7-13. doi: 10.1016/j.jtemb.2009.06.004. Epub 2009 Aug 8.

Abstract

New La(III) and Dy(III) complexes of deprotonated 4-hydroxy-3[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one (Acenocoumarol) were synthesized and characterized using FT-IR, FT-Raman, (1)H NMR spectra, and elemental analyses. The ligand and its lanthanide(III) complexes were tested for their cytotoxic/cytostatic activity against two tumor cell lines and peritoneal mouse macrophages. The La(III) and Dy(III) complexes exhibit good activity against melanoma B16 and fibrosarcoma L929 and they are stronger inhibitors of tumor cell proliferation compared to the ligand without influencing normal cell viability and NO release by mouse peritoneal macrophages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acenocoumarol / chemical synthesis
  • Acenocoumarol / chemistry*
  • Acenocoumarol / toxicity*
  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / toxicity*
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cytostatic Agents / chemistry*
  • Cytostatic Agents / toxicity
  • Dose-Response Relationship, Drug
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Dysprosium / chemistry*
  • Dysprosium / toxicity
  • Humans
  • Lanthanum / chemistry*
  • Lanthanum / toxicity
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Mice
  • Spectrum Analysis, Raman
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Cytostatic Agents
  • Ligands
  • Dysprosium
  • Lanthanum
  • Acenocoumarol