In vivo modulation of HMGA2 expression

Biochim Biophys Acta. Jan-Feb 2010;1799(1-2):55-61. doi: 10.1016/j.bbagrm.2009.11.013.

Abstract

While the biochemical role of the HMGA proteins has largely been elucidated in tissue culture, the majority of the insight as to their physiological functions in the processes of proliferation and development has been established in animal models of overexpression (transgenic) and null mice (knockouts). An emphasis has been placed on the HMGA2 studies which have defined its critical role in mesenchymal proliferation and differentiation.

Publication types

  • Review

MeSH terms

  • Adipogenesis
  • Animals
  • HMGA2 Protein / deficiency
  • HMGA2 Protein / genetics
  • HMGA2 Protein / metabolism*
  • Lipoma / metabolism
  • Male
  • Mice
  • Mice, Transgenic
  • Spermatogenesis
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Testis / cytology
  • Testis / metabolism

Substances

  • HMGA2 Protein