Cyclic antidepressants and the risk of hip fracture

Arch Intern Med. 1991 Apr;151(4):754-6.


To determine whether cyclic antidepressants increase the risk of hip fracture, we conducted a population-based case-control study in the Canadian province of Saskatchewan. We identified 4501 persons 65 years of age or older with a first hospitalization for hip fracture between 1977 and 1985 and 24,041 comparable controls. Current antidepressant users had a relative risk of hip fracture of 1.6 (95% confidence interval, 1.3 to 1.9). Medical record review for a sample of 164 cases suggested this finding was not due to confounding by body mass, impaired ambulation, functional status, or dementia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Accidental Falls*
  • Aged
  • Antidepressive Agents, Tricyclic / adverse effects*
  • Antidepressive Agents, Tricyclic / therapeutic use
  • Case-Control Studies
  • Confidence Intervals
  • Confounding Factors, Epidemiologic
  • Female
  • Hip Fractures / epidemiology*
  • Humans
  • Male
  • Odds Ratio
  • Risk Factors
  • Saskatchewan / epidemiology


  • Antidepressive Agents, Tricyclic