Multidisciplinary insights into optimizing adherence after solid organ transplantation

Transplantation. 2010 Mar 15;89(5):627-32. doi: 10.1097/TP.0b013e3181ca87b0.


Background: Nonadherence to medical treatment in transplant recipients is a major risk factor for graft rejection episodes, and it has significant financial implications. Despite its importance, there is a lack of common understanding across the disciplines involved of the key issues driving nonadherence.

Methods: A qualitative study, comprising a multidisciplinary workshop, followed by a consultation exercise to validate its outcomes, was initiated to gain further insight into nonadherence behavior and to identify priorities for optimizing adherence to posttransplantation regimens.

Results: Eight statements relating to actions necessary to maximize adherence to posttransplantation medication were developed and offered for validation. All but one of these attracted a median score of 9 on an agreement scale of 1 to 10, where 10 was the highest level of agreement.

Conclusion: The outcomes generate a structure that will facilitate communication and understanding and informing clinical practice and future research.

MeSH terms

  • Adult
  • Attitude to Health
  • Child
  • Culture
  • England
  • Graft Rejection / epidemiology
  • Graft Rejection / psychology
  • Heart Transplantation / psychology
  • Humans
  • Kidney Transplantation / psychology
  • Liver Transplantation / psychology
  • Organ Transplantation / psychology*
  • Patient Compliance*
  • Patient Education as Topic
  • Patients / psychology
  • Perception
  • Risk Factors
  • Surveys and Questionnaires
  • Wales