Epidemiology: Interpreting studies of interactions between RA risk factors

Elizabeth W Karlson; Karen H Costenbader

doi:10.1038/nrrheum.2009.276

Epidemiology: Interpreting studies of interactions between RA risk factors

Nat Rev Rheumatol. 2010 Feb;6(2):72-3. doi: 10.1038/nrrheum.2009.276.

Authors

Elizabeth W Karlson¹, Karen H Costenbader

Affiliation

¹ Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. ekarlson@partners.org

PMID: 20125172
DOI: 10.1038/nrrheum.2009.276

Abstract

Interactions between HLA and PTPN22 genotypes and smoking have been implicated in overall susceptibility to rheumatoid arthritis as well as the incidence of particular disease phenotypes in case-control and case-only studies. As recent epidemiological evidence shows, deciphering these interactions demands consideration of the analytical approach used.

Publication types

News

MeSH terms

Arthritis, Rheumatoid / genetics*
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Humans
Protein Tyrosine Phosphatase, Non-Receptor Type 22 / genetics*
Risk Factors
Smoking / adverse effects*

Substances

HLA-DR Antigens
HLA-DRB1 Chains
PTPN22 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 22