Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties

Chem Commun (Camb). 2010 Feb 21;46(7):1141-3. doi: 10.1039/b921616b. Epub 2009 Dec 16.


A new class of biodegradable materials was prepared by combining polyethylene glycol, heparin, and a matrix metalloproteinase-cleavable peptide sequence into a well-defined hydrogel network which mimics native extracellular matrices in its ability to provide mechanical support and chemical signals as well as elicit a dynamic reciprocal response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Heparin / chemistry*
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemical synthesis*
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry
  • Matrix Metalloproteinases / metabolism
  • Peptides / chemistry
  • Polyethylene Glycols / chemistry*
  • Spectrophotometry, Ultraviolet


  • Peptides
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Polyethylene Glycols
  • Heparin
  • Matrix Metalloproteinases