Potential of creatine supplementation for improving aging bone health

J Nutr Health Aging. 2010 Feb;14(2):149-53. doi: 10.1007/s12603-009-0224-5.


Aging subsequently results in bone and muscle loss which has a negative effect on strength, agility, and balance leading to increased risks of falls, injuries, and fractures. Resistance training is an effective strategy for maintaining bone mass, possibly by increasing activity of cells involved in bone formation and reducing activity of cells involved in bone resorption. However, bone loss is still evident in older adults who have maintained resistance training for most of their life, suggesting that other factors such as nutrition may be involved in the aging bone process. Emerging evidence suggests that creatine supplementation, with and without resistance training, has the potential to influence bone biology. However, research investigating the longer-term effects of creatine supplementation and resistance training on aging bone is limited.

Publication types

  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Bone Density / drug effects*
  • Bone Density / physiology
  • Creatine / administration & dosage
  • Creatine / therapeutic use*
  • Dietary Supplements
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscular Atrophy / drug therapy*
  • Resistance Training*
  • Risk Factors


  • Creatine