QuantiFERON-TB Gold In-Tube test (QFT-GIT) for the screening of latent tuberculosis in recent immigrants to Italy

New Microbiol. 2009 Oct;32(4):369-76.


To evaluate the agreement between QuantiFERON-TB Gold In-Tube test (QFT-GIT) and tuberculin skin test (TST) for the screening of latent tuberculosis infection (LTBI) in recent immigrants to Italy, 279 subjects were submitted to concomitant TST and QFT-GIT. The agreement was analyzed using k statistics. A total of 72/279 (25.8%) individuals were TST positive, while 107/279 (38.3%) were QFT-GIT positive. The overall agreement between QFT-GIT and TST was 70.9%, with k statistic of 0.35. Using different TST and QFT-GIT cut-offs, the best concordance value was obtained for QFT-GIT at > 2.64 IU/ml and TST at > 10mm (k = 0.409). Discordant results were found for 58 subjects (21%) with QFT-GIT positive/TST negative and 23 (8%) with QFT-GIT negative/TST positive. A high amount of discordance QFT-GIT+/TST- was described. QFT-GIT might increase the identification of LTBI cases among recent immigrants.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Emigrants and Immigrants*
  • Female
  • Humans
  • Interferon-gamma / blood*
  • Italy
  • Latent Tuberculosis / diagnosis*
  • Latent Tuberculosis / epidemiology
  • Male
  • Mass Screening / methods*
  • Mycobacterium tuberculosis / immunology
  • Reagent Kits, Diagnostic*
  • Skin Tests
  • Tuberculosis, Pulmonary / diagnosis
  • Tuberculosis, Pulmonary / epidemiology
  • Young Adult


  • Reagent Kits, Diagnostic
  • Interferon-gamma