Histone Acetylation by HBO1 Tightens Replication Licensing

Mol Cell. 2010 Jan 15;37(1):5-6. doi: 10.1016/j.molcel.2009.12.028.

Abstract

In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by HBO1 acetylating histone H4 at replication origins, providing a molecular view of how chromatin status influences origin usage.

Publication types

  • Comment

MeSH terms

  • Acetylation
  • Chromatin / metabolism
  • DNA Replication*
  • Histone Acetyltransferases / physiology*
  • Histones / metabolism*
  • Humans
  • Models, Genetic*

Substances

  • Chromatin
  • Histones
  • Histone Acetyltransferases
  • KAT7 protein, human