A tumor suppressor SIRTainty

Cancer Cell. 2010 Jan 19;17(1):5-6. doi: 10.1016/j.ccr.2009.12.032.


Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / metabolism*
  • Genes, Tumor Suppressor / physiology*
  • Humans
  • Mice
  • Mitochondria / metabolism*
  • Reactive Oxygen Species / metabolism
  • Sirtuin 3 / metabolism*
  • Stress, Physiological / physiology*


  • Reactive Oxygen Species
  • SIRT3 protein, human
  • Sirtuin 3