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. 2010 Jan 19;17(1):5-6.
doi: 10.1016/j.ccr.2009.12.032.

A Tumor Suppressor SIRTainty


A Tumor Suppressor SIRTainty

Paul T Schumacker. Cancer Cell. .


Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.

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