Automated and interactive lesion detection and segmentation in uterine cervix images

IEEE Trans Med Imaging. 2010 Feb;29(2):488-501. doi: 10.1109/TMI.2009.2037201.


This paper presents a procedure for automatic extraction and segmentation of a class-specific object (or region) by learning class-specific boundaries. We describe and evaluate the method with a specific focus on the detection of lesion regions in uterine cervix images. The watershed segmentation map of the input image is modeled using a Markov random field (MRF) in which watershed regions correspond to binary random variables indicating whether the region is part of the lesion tissue or not. The local pairwise factors on the arcs of the watershed map indicate whether the arc is part of the object boundary. The factors are based on supervised learning of a visual word distribution. The final lesion region segmentation is obtained using a loopy belief propagation applied to the watershed arc-level MRF. Experimental results on real data show state-of-the-art segmentation results on this very challenging task that, if necessary, can be interactively enhanced.

MeSH terms

  • Algorithms
  • Artificial Intelligence
  • Cervix Uteri / anatomy & histology*
  • Cervix Uteri / cytology
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Markov Chains
  • Photography / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Uterine Cervical Neoplasms / pathology*