Neuropsychiatric symptoms in korean patients with Alzheimer's disease: exploratory factor analysis and confirmatory factor analysis of the neuropsychiatric inventory

Dement Geriatr Cogn Disord. 2010;29(1):82-7. doi: 10.1159/000264629. Epub 2010 Feb 3.


Background/aims: We designed this study to examine subsyndromes in Korean patients with Alzheimer's disease (AD) using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA).

Methods: Initial participants were 778 AD patients recruited from the Clinical Research Center for Dementia of South Korea and assessed via the Korean Neuropsychiatric Inventory. Those with > or =1 neuropsychiatric symptom were randomly divided into groups. Principal axis factoring with oblimin rotation was used to analyze group 1 inventory results, and maximum likelihood estimation extraction with Bollen-Stine bootstrapping was used for group 2.

Results: The results of the EFA showed the presence of 4 subsyndromes: hyperactivity, affect, psychosis and apathy/vegetative symptom. The CFA results indicated this model was the best-fitting model for explaining these subsyndromes.

Conclusion: Our model showed the best fit and identified 4 subsyndromes. This study might contribute to a clearer understanding of the neuropsychiatric symptoms in AD.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Affect
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / psychology*
  • Behavior
  • Data Interpretation, Statistical
  • Factor Analysis, Statistical
  • Female
  • Humans
  • Hyperkinesis / psychology
  • Likelihood Functions
  • Male
  • Psychiatric Status Rating Scales / statistics & numerical data*
  • Psychotic Disorders / psychology
  • Republic of Korea