Role of Helicobacter pylori infection in gastric cancer pathogenesis: a chance for prevention

J Dig Dis. 2010 Feb;11(1):2-11. doi: 10.1111/j.1751-2980.2009.00408.x.


Gastric cancer in the absence of strategies implemented for early detection continues to have a dismal prognosis. There are limited options for a curative therapy once patients present with clinical manifestations of this malignant disease. Helicobacter pylori (H. pylori) infection plays a key role in gastric carcinogenesis, supported by epidemiological, preclinical and clinical studies. The recognition of H. pylori infection as a critical risk factor in the development of gastric cancer opens the chance for new venues in prevention strategies.

MeSH terms

  • Algorithms
  • Animals
  • Disease Models, Animal
  • Environment
  • Genetic Predisposition to Disease
  • Helicobacter Infections / drug therapy
  • Helicobacter Infections / microbiology*
  • Helicobacter pylori / pathogenicity*
  • Humans
  • Mass Screening / methods
  • Precancerous Conditions / diagnosis
  • Precancerous Conditions / microbiology
  • Stomach Neoplasms / etiology
  • Stomach Neoplasms / microbiology*
  • Stomach Neoplasms / prevention & control
  • Virulence Factors / physiology


  • Virulence Factors