Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery

Trends Endocrinol Metab. 2010 Jun;21(6):337-44. doi: 10.1016/j.tem.2010.01.006. Epub 2010 Feb 3.


Bariatric surgery is the most effective treatment modality for obesity, resulting in durable weight loss and amelioration of obesity-associated comorbidities, particularly type 2 diabetes mellitus (T2DM). Moreover, the metabolic benefits of bariatric surgery occur independently of weight loss. There is increasing evidence that surgically induced alterations in circulating gut hormones mediate these beneficial effects of bariatric surgery. Here, we summarise current knowledge on the effects of different bariatric procedures on circulating gut hormone levels. We also discuss the theories that have been put forward to explain the weight loss and T2DM resolution following bariatric surgery. Understanding the mechanisms mediating these beneficial outcomes of bariatric surgery could result in new non-surgical treatment strategies for obesity and T2DM.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bariatric Surgery* / classification
  • Bariatric Surgery* / methods
  • Caloric Restriction*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / surgery
  • Energy Metabolism
  • Ghrelin / metabolism
  • Glucagon-Like Peptide 1 / metabolism
  • Humans
  • Obesity / metabolism
  • Obesity / surgery*
  • Peptide YY / metabolism
  • Weight Loss / physiology*


  • Ghrelin
  • Peptide YY
  • Glucagon-Like Peptide 1