Common polymorphisms of Fibulin-5 and the risk of abdominal aortic aneurysm development

Vasc Med. 2010 Apr;15(2):113-7. doi: 10.1177/1358863X09355667. Epub 2010 Feb 4.


Fibulin-5 is a crucial protein in the connective tissue structure of the aortic wall. The purpose of this study was to determine if genetic variation within the Fibulin-5 gene was associated with abdominal aortic aneurysms (AAA). AAA patients, with disease-free controls, were recruited and a past medical history questionnaire completed. Three single nucleotide polymorphisms (SNPs) in the FBLN5 gene (rs2498834, rs2430366 and rs2254320) were genotyped. The two cohorts were compared and haplotype analysis performed. A total of 230 AAA cases and 278 controls were successfully genotyped. The mean age was 71.9 years (+/- 6.8). No difference between cases and controls was found in the distribution of alleles of FBLN5 SNPs rs2498834 (p = 0.47), rs2430366 (p = 0.45) or rs2254320 (p = 0.46). Haplotype analysis did not reveal any significant difference. In conclusion, genetic variation within FBLN5 is unlikely to play any role in the development of AAA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aortic Aneurysm, Abdominal / epidemiology*
  • Aortic Aneurysm, Abdominal / genetics*
  • Chromosomes, Human, Pair 14*
  • Extracellular Matrix Proteins / genetics*
  • Genetic Predisposition to Disease / epidemiology
  • Haplotypes
  • Humans
  • Middle Aged
  • Polymorphism, Genetic*
  • Risk Factors


  • Extracellular Matrix Proteins
  • FBLN5 protein, human