Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris

Circ J. 2010 Mar;74(3):589-91. doi: 10.1253/circj.cj-09-1028. Epub 2010 Feb 4.


Background: Low-energy shock wave (SW) therapy has improved myocardial ischemia in both a porcine model and in patients with severe angina pectoris.

Methods and results: To further confirm the effectiveness and safety of SW therapy, 8 patients with severe angina pectoris were treated with SW therapy in a double-blind, placebo-controlled and cross-over manner. SW therapy, but not placebo, significantly improved chest pain symptoms and cardiac function without any complications or adverse effects.

Conclusions: Extracorporeal cardiac SW therapy is an effective, safe and non-invasive therapeutic option for severe angina pectoris.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Angina Pectoris / therapy*
  • Chest Pain / therapy*
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Humans
  • Lithotripsy / adverse effects
  • Lithotripsy / methods*
  • Male
  • Middle Aged
  • Placebos
  • Severity of Illness Index
  • Treatment Outcome
  • Ultrasonic Therapy / adverse effects
  • Ultrasonic Therapy / methods*


  • Placebos