Immunomodulatory activity of type-4 resistant starch in the mesenteric lymph nodes of rats

J Med Food. 2010 Feb;13(1):205-10. doi: 10.1089/jmf.2009.1170.


We evaluated the immunomodulatory activity of type-4 resistant starch (RS) in mesenteric lymph nodes (MLNs) using a rat model. Sixteen male Sprague-Dawley rats were fed either a cellulose diet or an RS diet (RSD) for 4 weeks. Serum immunoglobulin A levels, as well as the CD4(+) T cell population and the ratio of CD4(+)/CD8(+) T cells in the MLNs of rats, were significantly elevated by replacing cellulose with RS in the diet. The survival rate of concanavalin A (Con A)-stimulated MLN lymphocytes and interleukin-4 secretion from the Con A-stimulated MLN lymphocytes were significantly increased in rats fed RSD. These results indicate that type-4 RS might ameliorate allergic inflammation in the MLNs of rats through an increased CD4(+) T cell population and enhanced differentiation of MLN lymphocytes into type-2 T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD4-CD8 Ratio
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / drug effects
  • CD8-Positive T-Lymphocytes / metabolism
  • Cell Differentiation / drug effects
  • Cell Survival / drug effects
  • Cellulose
  • Concanavalin A
  • Dietary Carbohydrates / administration & dosage*
  • Hypersensitivity / drug therapy
  • Immunoglobulin A / blood*
  • Immunologic Factors / pharmacology*
  • Immunologic Factors / therapeutic use
  • Inflammation / drug therapy*
  • Interleukin-4 / metabolism
  • Lymph Nodes / drug effects*
  • Lymph Nodes / immunology
  • Lymphocytes / drug effects*
  • Lymphocytes / metabolism
  • Male
  • Mesentery
  • Rats
  • Rats, Sprague-Dawley
  • Starch / pharmacology*
  • Starch / therapeutic use
  • Th2 Cells / drug effects
  • Th2 Cells / metabolism


  • Dietary Carbohydrates
  • Immunoglobulin A
  • Immunologic Factors
  • Concanavalin A
  • Interleukin-4
  • Cellulose
  • Starch