The efficacy of multiple-dose methotrexate treatment for unruptured tubal ectopic pregnancy and conversion rate to surgery: a study on 294 cases

Fertil Steril. 2010 May 1;93(7):2415-7. doi: 10.1016/j.fertnstert.2009.09.014. Epub 2010 Feb 4.

Abstract

In this prospective study 294 patients diagnosed with ectopic pregnancy (EP) were treated with multiple-dose methotrexate (MTX) to determine the conversion rate to surgery. We concluded that multiple-dose MTX treatment had a low success rate, and the success rate was not related to initial b-hCG value; it was more related to the size of gestational mass before treatment.

Publication types

  • Clinical Trial

MeSH terms

  • Abortifacient Agents, Nonsteroidal / administration & dosage
  • Adult
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Embryo, Mammalian / pathology
  • Fallopian Tubes / drug effects
  • Fallopian Tubes / pathology
  • Female
  • Follow-Up Studies
  • Gestational Age
  • Gynecologic Surgical Procedures / statistics & numerical data*
  • Humans
  • Injections, Intramuscular
  • Methotrexate / administration & dosage*
  • Organ Size
  • Pregnancy
  • Pregnancy, Ectopic / drug therapy*
  • Pregnancy, Ectopic / epidemiology
  • Pregnancy, Ectopic / pathology
  • Pregnancy, Ectopic / surgery*
  • Treatment Failure
  • Treatment Outcome

Substances

  • Abortifacient Agents, Nonsteroidal
  • Methotrexate