Use of the metabolic tracer carbon-11-acetate for evaluation of regional myocardial perfusion

J Nucl Med. 1991 Apr;32(4):665-72.


The high first-pass myocardial extraction fraction of carbon-11-acetate suggests that its initial uptake depends on blood flow. Accordingly, regional uptake of 11C-acetate at 4 min was compared to regional perfusion determined with nitrogen-13-ammonia in 119 segments in 15 patients with stable coronary artery disease by two methods. A close correlation was observed between initial relative myocardial concentrations (segmental activity normalized to maximal activity) of both tracers (11C-acetate = 0.88; 13N-ammonia + 0.079; s.e.e. = 0.064, r = 0.94, p less than 0.001). Furthermore, segmental net extractions (E.F), as calculated from the input function and segmental activities, of the two tracers correlated closely by E.FC-11 = 0.55E.FN-13 + 0.080 (s.e.e. = 0.045, r = 0.87, p less than 0.001). These relationships indicate that initial regional myocardial uptake of 11C-acetate reflects perfusion and that 11C-acetate permits near simultaneous evaluation of regional oxidative metabolism and of regional myocardial perfusion.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetates*
  • Aged
  • Ammonia
  • Carbon Radioisotopes
  • Coronary Circulation*
  • Coronary Disease / diagnostic imaging*
  • Coronary Disease / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nitrogen Radioisotopes
  • Tomography, Emission-Computed*


  • Acetates
  • Carbon Radioisotopes
  • Nitrogen Radioisotopes
  • Ammonia