Current knowledge of the pre-autophagosomal structure (PAS)

FEBS Lett. 2010 Apr 2;584(7):1280-6. doi: 10.1016/j.febslet.2010.02.001. Epub 2010 Feb 5.


Autophagy is a system for degradation of bulk cellular components in lytic compartments, vacuoles, or lysosomes when eukaryotic cells face with nutrient starvation. In this review, we focus on the pre-autophagosomal structure (PAS), a functional entity responsible for autophagosome formation in Saccharomyces cerevisiae, and discuss its relevance to autophagy in mammalian cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Autophagy* / genetics
  • Models, Biological
  • Phagosomes / metabolism*
  • Saccharomyces cerevisiae / cytology*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism


  • Saccharomyces cerevisiae Proteins