Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors

Atherosclerosis. 2010 Jul;211(1):278-82. doi: 10.1016/j.atherosclerosis.2010.01.015. Epub 2010 Jan 25.

Abstract

Palm oil is enriched in vitamin E in the form of alpha-, gamma-, and delta-tocotrienols. Dietary tocotrienol supplements have been shown to prevent atherosclerosis development in patients and preclinical animal models. However, the mechanistic basis for this health beneficial effect is not well established. Peroxisome proliferator-activated receptors alpha, gamma, and delta (PPARalpha, PPARgamma, and PPARdelta) are ligand regulated transcription factors that play essential preventive roles in the development of atherosclerosis through regulating energy metabolism and inflammation. In this study, we presented data that the tocotrienol rich fraction (TRF) of palm oil activated PPARalpha, PPARgamma, and PPARdelta in reporter based assays. Importantly, TRF attenuated the development of atherosclerosis in ApoE-/- mice through inducing PPAR target gene liver X receptor alpha (LXRalpha) and its down-stream target genes apolipoproteins and cholesterol transporters, suggesting that modulating the activities of PPARs is a key aspect of the in vivo action of tocotrienols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apolipoproteins E / deficiency
  • Atherosclerosis / prevention & control*
  • Chromans / pharmacology
  • Humans
  • Liver X Receptors
  • Male
  • Mice
  • Orphan Nuclear Receptors / metabolism
  • PPAR alpha / metabolism
  • Palm Oil
  • Peroxisome Proliferator-Activated Receptors / drug effects*
  • Peroxisome Proliferator-Activated Receptors / pharmacology*
  • Peroxisome Proliferator-Activated Receptors / physiology
  • Plant Oils / pharmacology*
  • Tocotrienols
  • Tumor Cells, Cultured
  • Vitamin E / analogs & derivatives
  • Vitamin E / pharmacology

Substances

  • Apolipoproteins E
  • Chromans
  • Liver X Receptors
  • NR1H3 protein, human
  • Nr1h3 protein, mouse
  • Orphan Nuclear Receptors
  • PPAR alpha
  • Peroxisome Proliferator-Activated Receptors
  • Plant Oils
  • Tocotrienols
  • Vitamin E
  • tocotrienol, delta
  • plastochromanol 8
  • Palm Oil
  • tocotrienol, alpha